Buy BPC-157 – Peptide Partners

Product Overview & Specifications

BPC-157 is a synthetic research peptide supplied by Peptide Partners for in-vitro testing, laboratory experimentation, and preclinical research. Current research has examined BPC-157 in cellular systems and animal models involving tendon fibroblasts, endothelial signaling, angiogenesis-related assays, vasomotor responses, and nitric oxide pathways.

Research findings involving BPC-157 include changes in growth hormone receptor expression, VEGFR2-related signaling, endothelial tube formation, Src-Caveolin-1-eNOS activity, and nitric oxide production. These findings are limited to laboratory and preclinical models and do not establish human safety, efficacy, or clinical outcomes.

Product Specifications

The stated 99.66% purity is based on multi-vial testing. Researchers should review the applicable batch documentation and certificate of analysis before beginning any experiment.

Primary Research Studies & Findings

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

Authors: Chung-Hsun Chang, Wen-Chung Tsai, Ya-Hui Hsu, and Jong-Hwei Su Pang

Publication source: Molecules, 2014;19(11):19066

Reference: View publication

This in-vitro study investigated BPC-157 in rat Achilles tendon fibroblasts. The researchers evaluated growth hormone receptor expression at the messenger RNA and protein levels, as well as cell-proliferation markers and downstream signaling activity.

The study reported dose- and time-dependent changes in growth hormone receptor expression following BPC-157 exposure. In the experimental system, the addition of growth hormone to BPC-157-treated fibroblasts was associated with increased cell-proliferation measurements and activation of Janus kinase 2 (JAK2), a downstream component of growth hormone receptor signaling.

Plain-English Research Summary

This laboratory study examined how BPC-157 affects tendon-derived cells. The researchers observed changes in growth hormone receptor expression and related signaling when the peptide was tested in cultured fibroblasts. The results describe cellular responses in an experimental model and do not establish tissue-repair effects or clinical outcomes in humans.

Therapeutic Potential of Pro-Angiogenic BPC157 Is Associated With VEGFR2 Activation and Up-Regulation

Authors: Ming-Jer Hsieh, Hsien-Ta Liu, Chao-Nin Wang, Hsiu-Yun Huang, Yuling Lin, Yu-Shien Ko, Jong-Shyan Wang, Vincent Hung-Shu Chang, and Jong-Hwei S. Pang

Publication source: Journal of Biomedical Science, 2017

Reference: PubMed 27847966

This study examined BPC-157 in human umbilical vein endothelial cells and animal models. In vitro, the researchers evaluated endothelial tube formation, vascular endothelial growth factor receptor 2 (VEGFR2) expression, receptor internalization, and downstream Akt-eNOS signaling.

The study reported increased endothelial tube formation and changes in VEGFR2 expression following BPC-157 exposure. It also examined VEGFR2 internalization and activation of the VEGFR2-Akt-eNOS signaling pathway. Inhibition of endocytosis reduced the observed responses in the experimental system, supporting a role for receptor internalization in the signaling process.

Plain-English Research Summary

This study explored how BPC-157 affects endothelial cells in laboratory assays. The researchers examined tube-like structures and a signaling pathway involving VEGFR2, Akt, and eNOS. These findings may help characterize the peptide’s cellular mechanism in angiogenesis-related research, but they do not demonstrate therapeutic activity or human benefit.

Modulatory Effects of BPC 157 on Vasomotor Tone and the Activation of the Src-Caveolin-1-Endothelial Nitric Oxide Synthase Pathway

Authors: Ming-Jer Hsieh, Cheng-Hung Lee, Ho-Yen Chueh, Gwo-Jyh Chang, Hsiu-Yun Huang, Yuling Lin, and Jong-Hwei S. Pang

Publication source: Scientific Reports, 2020

Reference: View publication

This study investigated the effects of BPC-157 on vascular responses using isolated rat aorta and vascular endothelial-cell experiments. The researchers assessed vasomotor tone, nitric oxide production, endothelial-cell migration, and phosphorylation of Src, Caveolin-1, and endothelial nitric oxide synthase (eNOS).

The study reported concentration-dependent, endothelium-dependent vasodilation in isolated rat aorta. In endothelial-cell experiments, BPC-157 was associated with increased nitric oxide production and cell migration. Additional analyses indicated that the Src-Caveolin-1-eNOS signaling pathway was involved in the observed responses, while Src inhibition reduced those effects.

Plain-English Research Summary

This research examined how BPC-157 influences vascular-cell signaling in isolated tissues and laboratory cell systems. The study focused on nitric oxide production and the Src-Caveolin-1-eNOS pathway, which are relevant to endothelial biology. The results are mechanistic and preclinical and should not be interpreted as evidence of a human vascular or healing treatment effect.

Standard Research Disclaimer

Research Use Only. Not for use in diagnostic tests.

This product is solely intended for research purposes as a chemical compound. It is designated exclusively for in-vitro testing and laboratory experimentation. All information provided about this product is educational and should be evaluated by appropriately qualified research personnel.

By law, bodily introduction of this product into humans or animals is strictly prohibited. This compound must not be used, administered, or represented as a drug, food, dietary supplement, cosmetic, diagnostic material, or medical treatment. It is not intended to diagnose, treat, cure, or prevent any disease. It should be handled only by licensed and qualified professionals in an appropriately equipped laboratory and in accordance with applicable laws, institutional procedures, and relevant safety requirements.